Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19647226 | 1.00 | OPRM1 (0.41) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 | |
| SCHEMBL19647087 | 0.87 | AKR1C1 (0.40) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 | |
| SCHEMBL16015556 | 0.81 | OPRM1 (0.43) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 | |
| SCHEMBL14962755 | 0.81 | HSP90AA1 (0.37) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 | |
| SCHEMBL2569600 | 0.76 | OPRM1 (0.42) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 | |
| SCHEMBL27742157 | 0.76 | AKR1C1 (0.42) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 | |
| SCHEMBL20054995 | 0.75 | OPRM1 (0.37) | OPRM1OPRL1SMN1; SMN2APOBEC3AAPOBEC3G | |
| SCHEMBL17215183 | 0.73 | AKR1C1 (0.40) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 | |
| SCHEMBL19647190 | 0.72 | SLC6A2 (0.51) | OPRM1OPRL1SMN1; SMN2CYP2D6SLC6A2 | |
| SCHEMBL20876291 | 0.72 | CYP2D6 (0.42) | OPRM1OPRL1AKR1C1ALDH1A1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |