Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24642489 | 0.86 | CHEK2 (0.47) | MAPK1JAK2JAK3TNKS | |
| SCHEMBL25697123 | 0.86 | MAPK1 (0.50) | MAPK1MAPK14KDRRPS6KA3EGFR | |
| SCHEMBL27432231 | 0.84 | HSD17B1 (0.44) | MAPK1JAK2PARP1GAA | |
| SCHEMBL20289959 | 0.83 | JAK1 (0.41) | MAPK1MAPK14JAK2CDK8KDR | |
| SCHEMBL25697037 | 0.82 | CCNT1 (0.38) | MAPK1MAPK14JAK2PRKD3MAP4K4 | |
| SCHEMBL25696601 | 0.82 | TNKS (0.46) | JAK2KDRTNKSTNKS2 | |
| SCHEMBL20290060 | 0.82 | JAK1 (0.44) | MAPK1MAPK14JAK2KDRRPS6KA3 | |
| SCHEMBL25696885 | 0.82 | MAPK1 (0.53) | MAPK1JAK2JAK3TNKSPARP1 | |
| SCHEMBL25696739 | 0.82 | NPC1 (0.49) | MAPK1MAPK14JAK2CDK8IKBKB | |
| SCHEMBL27439654 | 0.81 | KDM4E (0.48) | KDRCDK5NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4393923-A1 | PYRIDO RING COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATION | Yiyou Biotech (Shanghai) Co., Ltd. (CN) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023115327-A1 | PYRIDO RING COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATION | 中国药科大学 | 2023-06-29 | — | — | WO | disclosed |