Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11378515 | 0.84 | ABCB1 (0.57) | SCD5ABCB1GABRA1GABRG2GABRB3 | |
| SCHEMBL23572508 | 0.83 | HCRTR1 (0.44) | HCRTR1HCRTR2CYP3A4SCD5CHRNB2 | |
| SCHEMBL25698255 | 0.83 | HRH3 (0.57) | HCRTR1HCRTR2CHRNB4CHRNA3 | |
| SCHEMBL23477849 | 0.83 | HCRTR1 (0.44) | HCRTR1HCRTR2CYP3A4SCD5CHRNB2 | |
| SCHEMBL29997813 | 0.83 | HCRTR1 (0.44) | HCRTR1HCRTR2CYP3A4SCD5CHRNB2 | |
| SCHEMBL25698242 | 0.83 | DPP4 (0.46) | SCD5ABCB1GABRA1GABRG2GABRB3 | |
| SCHEMBL27651068 | 0.80 | HSD11B1 (0.58) | SCD5ABCB1 | |
| SCHEMBL11379853 | 0.80 | CHRNB4 (0.62) | CHRNB2CHRNB4CHRNA3CHRNA4ADRA1D | |
| SCHEMBL11481440 | 0.79 | HSD11B1 (0.57) | SCD5ABCB1 | |
| SCHEMBL25698280 | 0.78 | HSD11B1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | ATM, CHEK2, CHEK1 | HCRTR1 4861/4885HCRTR2 4823/4885CYP3A4 4493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.