Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.52 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.52 |
| ▸ | EED | O75530 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23459022 | 0.86 | ABHD6 (0.54) | HRH3ABHD6DAGLAEEDHCRTR1 | |
| SCHEMBL25698266 | 0.85 | ATM (0.55) | HRH3ABHD6DAGLAEEDHCRTR1 | |
| SCHEMBL3640317 | 0.85 | HRH3 (0.53) | HRH3ABHD6DAGLAEEDHCRTR1 | |
| SCHEMBL25698247 | 0.84 | HRH3 (0.54) | HRH3ABHD6DAGLAHCRTR1HCRTR2 | |
| SCHEMBL25698254 | 0.83 | HCRTR1 (0.47) | HCRTR1HCRTR2CHRNB4CHRNA3 | |
| SCHEMBL25698252 | 0.83 | ATM (0.55) | HRH3ABHD6DAGLAHCRTR1HCRTR2 | |
| SCHEMBL11379154 | 0.81 | CHRNB4 (0.66) | HRH3EEDATMCHRNB4CHRNA3 | |
| SCHEMBL11378515 | 0.81 | ABCB1 (0.57) | ABHD6DAGLAMEN1KMT2A | |
| SCHEMBL6985734 | 0.80 | HCRTR1 (0.56) | HRH3ABHD6DAGLAHCRTR1HCRTR2 | |
| SCHEMBL25698281 | 0.80 | ABHD6 (0.52) | HRH3ABHD6DAGLAHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | ATM, CHEK2, CHEK1 | HRH3 3954/4885ABHD6 3275/4885DAGLA 3969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.