SCHEMBL2569866

SCHEMBL2569866

CN1CCN(Cc2ccc(O)c(C(=O)Nc3cc(-c4ccccc4)ccc3C(=O)O)c2)CC1

nearest known ligand 0.69

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 11/20 0.69
SUCNR1 Q9BXA5 2/20 0.54
BACE1 P56817 1/20 0.48
PDCD1 Q15116 1/20 0.47
CD274 Q9NZQ7 1/20 0.47
CHKA P35790 1/20 0.46
ACLY P53396 2/20 0.46
WDR5 P61964 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316066 0.96 HDAC1 (0.65) HDAC1SUCNR1BACE1PDCD1CD274
SCHEMBL1316154 0.93 HDAC1 (0.61) HDAC1SUCNR1BACE1PDCD1CD274
SCHEMBL12117913 0.92 HDAC1 (0.59) HDAC1SUCNR1BACE1PDCD1CD274
SCHEMBL1316730 0.91 HDAC1 (0.60) HDAC1SUCNR1ACLYWDR5
SCHEMBL13206290 0.90 HDAC1 (0.56) HDAC1SUCNR1BACE1ACLY
SCHEMBL12117920 0.90 HDAC1 (0.55) HDAC1BACE1ACLY
Hydrochloric Acid SCHEMBL1315802 0.89 HDAC1 (0.54) HDAC1BACE1ACLY
SCHEMBL2571414 0.89 HDAC1 (0.55) HDAC1SUCNR1BACE1PDCD1CD274
SCHEMBL1315936 0.89 HDAC1 (0.55) HDAC1SUCNR1BACE1PDCD1CD274
SCHEMBL12117923 0.88 HDAC1 (0.69) HDAC1BACE1ACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed
WO-2010087430-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF 富山化学工業株式会社 (JP) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 HDAC1 73/4885SUCNR1 1233/4885BACE1 3622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.