Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25698688 | 0.88 | CYP1A2 (0.43) | DGAT1HIF1APRMT5WDR77AAK1 | |
| SCHEMBL16923787 | 0.84 | JAK2 (0.43) | DGAT1HIF1APRMT5WDR77AAK1 | |
| SCHEMBL25698689 | 0.82 | MAP4K1 (0.46) | MAP4K1DGAT1HIF1ABUB1PRMT5 | |
| SCHEMBL29393739 | 0.82 | PRMT5 (0.48) | DGAT1HIF1APRMT5WDR77AAK1 | |
| SCHEMBL9979047 | 0.82 | PRMT5 (0.48) | DGAT1HIF1APRMT5WDR77AAK1 | |
| SCHEMBL477041 | 0.81 | HIF1A (0.42) | DGAT1HIF1AGSK3AGSK3BPDGFRB | |
| SCHEMBL29429879 | 0.81 | L3MBTL1 (0.44) | HIF1AGSK3AGSK3BPDGFRBKDR | |
| SCHEMBL626853 | 0.81 | L3MBTL1 (0.44) | HIF1AGSK3AGSK3BPDGFRBKDR | |
| SCHEMBL1555262 | 0.80 | HIF1A (0.47) | DGAT1HIF1AGSK3AGSK3BABL1 | |
| SCHEMBL28749629 | 0.78 | AAK1 (0.40) | DGAT1HIF1APRMT5WDR77AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257352-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-08-17 | — | — | US | disclosed |
| US-20230257352-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-08-17 | — | — | US | disclosed |
| WO-2023108108-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257352-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | MAP4K1 30/4885DGAT1 2091/4885HIF1A 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.