SCHEMBL477041

SCHEMBL477041

CC1(C)OB(c2ccnc(NC(=O)O)c2)OC1(C)C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 3/20 0.42
PDGFRB P09619 2/20 0.41
KDR P35968 2/20 0.41
GSK3A P49840 1/20 0.40
GSK3B P49841 1/20 0.40
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
PKM P14618 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
DGAT1 O75907 1/20 0.38
LIPG Q9Y5X9 2/20 0.37
LPL P06858 1/20 0.37
P4HB P07237 1/20 0.36
SORT1 Q99523 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
F2 P00734 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL626853 0.89 L3MBTL1 (0.44) HIF1APDGFRBKDRGSK3AGSK3B
SCHEMBL29429879 0.89 L3MBTL1 (0.44) HIF1APDGFRBKDRGSK3AGSK3B
SCHEMBL16923787 0.86 JAK2 (0.43) HIF1APDGFRBKDRGSK3AGSK3B
SCHEMBL23410324 0.85 NPC1 (0.53) PDGFRBKDRNPC1RAB9APKM
SCHEMBL29514396 0.85 GSK3A (0.45) HIF1APDGFRBKDRGSK3AGSK3B
SCHEMBL28992879 0.85 PIK3C3 (0.41) HIF1APDGFRBKDRGSK3AGSK3B
SCHEMBL25698688 0.85 CYP1A2 (0.43) HIF1APDGFRBKDRGSK3AGSK3B
SCHEMBL1554702 0.85 GSK3A (0.45) HIF1APDGFRBKDRGSK3AGSK3B
SCHEMBL1555357 0.85 TYK2 (0.44) HIF1AGSK3AGSK3BNPC1RAB9A
SCHEMBL1554915 0.84 ACVRL1 (0.50) GSK3AGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12006316-B2 9H-pyrrolo-dipyridine derivatives UCB Biopharma SRL (BE) 2024-06-11 US disclosed
WO-2024108009-A1 DYRK/CLK PROTACS AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-05-23 WO disclosed
WO-2024078649-A1 SUBSTITUTED FUROPYRIDINES FOR THERAPEUTIC USE MASARYKOVA UNIVERZITA (CZ) 2024-04-18 WO disclosed
EP-4353727-A1 SUBSTITUTED FUROPYRIDINES FOR THERAPEUTIC USE Masarykova Univerzita (CZ) 2024-04-17 EP disclosed
EP-4337259-A1 COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF Aprinoia Therapeutics Limited (HK) 2024-03-20 EP disclosed
WO-2024049976-A1 N-METHYL-4-(QUINOLIN-2-YL)PYRIDIN-2-AMINE COMPOUNDS ABBVIE INC. (US) 2024-03-07 WO disclosed
EP-3615537-B1 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS NOVARTIS AG (CH) 2024-03-06 EP disclosed
WO-2023250083-A1 SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2023-12-28 WO disclosed
WO-2023250082-A2 SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2023-12-28 WO disclosed
US-20230406838-A1 MUTANT SELECTIVE EGFR INHIBITORS AND METHODS OF USE THEREOF DANA-FARBER CANCER INSTITUTE, INC. 2023-12-21 US disclosed
WO-2012175513-A1 THIENYLPYRI(MI)DINYLPYRAZOLE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2012-12-27 WO disclosed
EP-2516423-A1 THIENYLPYRI (MI) DINYLAZOLE AND THEIR USE FOR CONTROLLING PHYTOPATHOGENIC FUNGI Bayer CropScience AG (DE) 2012-10-31 EP disclosed
EP-2331546-B1 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF SANOFI SA (FR) 2012-02-01 EP disclosed
US-20110312934-A1 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF SANOFI-AVENTIS (FR) 2011-12-22 US disclosed
WO-2011076725-A1 THIENYLPYRI (MI) DINYLAZOLE AND THEIR USE FOR CONTROLLING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AG (DE) 2011-06-30 WO disclosed
EP-2331546-A1 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF Sanofi-aventis (FR) 2011-06-15 EP disclosed
US-20100179154-A1 6-CYCLOAMINO-3-(PYRID-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-07-15 US disclosed
EP-2170889-A2 6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZOÝ1,2-B¨PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2010-04-07 EP disclosed
WO-2010018327-A1 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF SANOFI-AVENTIS (FR) 2010-02-18 WO disclosed
WO-2009016286-A2 6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2009-02-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312934-A1 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF NR3C1, CNKSR1, NR3C2 HIF1A 3448/4885PDGFRB 429/4885KDR 261/4885
US-20230406838-A1 MUTANT SELECTIVE EGFR INHIBITORS AND METHODS OF USE THEREOF EGFR, ERBB2, ERBB3 HIF1A 2322/4885PDGFRB 23/4885KDR 44/4885
US-12006316-B2 9H-pyrrolo-dipyridine derivatives MAPT, PSEN1, PRNP HIF1A 3657/4885PDGFRB 407/4885KDR 2801/4885
US-20100179154-A1 6-CYCLOAMINO-3-(PYRID-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF CBR3, DHFR, IL4I1 HIF1A 4157/4885PDGFRB 122/4885KDR 643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.