Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 13/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | PARP12 | Q9H0J9 | 3/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.40 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25699730 | 0.85 | TIPARP (0.42) | TIPARPCHRM2CHRM1PARP12TNKS2 | |
| SCHEMBL30390013 | 0.85 | TIPARP (0.42) | TIPARPCHRM2CHRM1PARP12TNKS2 | |
| SCHEMBL30390426 | 0.85 | TIPARP (0.42) | TIPARPCHRM2CHRM1PARP12TNKS2 | |
| SCHEMBL25268928 | 0.84 | TIPARP (0.52) | TIPARPPARP12TNKS2PARP2PARP14 | |
| SCHEMBL31724031 | 0.83 | CHRM2 (0.52) | TIPARPCHRM2CHRM1GPR119PPARG | |
| SCHEMBL25261117 | 0.82 | TIPARP (0.55) | TIPARPCHRM2CHRM1PARP12TNKS2 | |
| SCHEMBL25223832 | 0.82 | TIPARP (0.49) | TIPARPCHRM2CHRM1PARP12TNKS2 | |
| SCHEMBL24968329 | 0.81 | DRD2 (0.54) | TIPARPCHRM2CHRM1PPARGPPARD | |
| SCHEMBL30859786 | 0.81 | TIPARP (0.46) | TIPARPPARP12TNKS2PARP2TNKS | |
| SCHEMBL24968158 | 0.81 | SIGMAR1 (0.47) | TIPARPCHRM2CHRM1PARP12TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | PIR, CYP3A43, CYP1A2 | TIPARP 3487/4885CHRM2 2493/4885CHRM1 1130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.