Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.30 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15343434 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2SIGMAR1HSD11B1MAPTTSHR | |
| SCHEMBL14067190 | 0.83 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTTSHRCHRNB2CHRNA3 | |
| SCHEMBL10237829 | 0.78 | PIK3CD (0.48) | SMN1; SMN2 | |
| SCHEMBL16456476 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2HSD11B1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL12337283 | 0.75 | KMT2A (0.33) | SMN1; SMN2SIGMAR1HSD11B1TSHR | |
| SCHEMBL4317775 | 0.75 | ARG1 (0.35) | SMN1; SMN2 | |
| SCHEMBL18081175 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTTSHRCHRNB2CHRNA3 | |
| SCHEMBL14590483 | 0.75 | CHRNB2 (0.48) | SMN1; SMN2MAPTTSHRCHRNB2CHRNA3 | |
| SCHEMBL357505 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTTSHRCHRNB2CHRNA3 | |
| SCHEMBL26241593 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTTSHRCHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107606-A1 | BCL-XL/BCL-2 DUAL DEGRADERS FOR TREATMENT OF CANCERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-06-15 | — | — | WO | disclosed |