Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 7/20 | 0.37 |
| ▸ | HTR1B | P28222 | 7/20 | 0.37 |
| ▸ | HTR1D | P28221 | 6/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5953065 | 0.78 | TTK (0.62) | TTKMAPK8HSD17B10KDM4EMAPT | |
| SCHEMBL2569461 | 0.77 | TTK (0.74) | TTKMAPK8CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2569442 | 0.76 | TRPA1 (0.51) | SMN1; SMN2KDM4E | |
| SCHEMBL16023544 | 0.75 | TTK (0.43) | TTKMAPK8HTR1AHTR1BHTR1D | |
| SCHEMBL2561086 | 0.75 | TTK (0.59) | TTKSMN1; SMN2HTR1ATP53CYP1A2 | |
| SCHEMBL2574384 | 0.70 | TTK (0.55) | TTKHTR1DKDM4EMAPT | |
| SCHEMBL5952020 | 0.70 | ALDH1A1 (0.53) | TTKHSD17B10KDM4EMAPTHTR2A | |
| SCHEMBL29923833 | 0.70 | ALDH1A1 (0.53) | TTKHSD17B10KDM4EMAPTHTR2A | |
| SCHEMBL27688753 | 0.70 | HTR1D (0.45) | TTKMAPK8LMNAHTR1DKDM4E | |
| SCHEMBL2558896 | 0.69 | TRPA1 (0.49) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |