Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2568967 | 0.80 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL14930174 | 0.78 | ERN1 (0.51) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL640919 | 0.73 | KDM4E (0.69) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28827512 | 0.69 | PDE5A (0.50) | ALDH1A1PARP1FGFR1FGFR2L3MBTL1 | |
| SCHEMBL31690222 | 0.69 | MAPT (0.50) | ALDH1A1KDM4EMAPTCYP1A2HSP90AA1 | |
| SCHEMBL26247344 | 0.69 | MAPT (0.50) | ALDH1A1KDM4EMAPTCYP1A2HSP90AA1 | |
| SCHEMBL8648025 | 0.68 | PARP1 (0.67) | PARP1FGFR1FGFR2L3MBTL1GUSB | |
| SCHEMBL1483159 | 0.68 | KDM4E (0.48) | ALDH1A1KDM4EMAPTCYP1A2CYP2C9 | |
| SCHEMBL30104672 | 0.68 | PDE5A (0.63) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL26088586 | 0.68 | PDE5A (0.63) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555768-A2 | IRE-1 INHIBITORS | MannKind Corporation (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127070-A2 | IRE-1α INHIBITORS | MANNKIND CORPORATION (US) | 2011-10-13 | — | — | WO | disclosed |