Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.69 |
| ▸ | RAB9A | P51151 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | PKM | P14618 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.63 |
| ▸ | RELA | Q04206 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30104672 | 0.85 | PDE5A (0.63) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL26088586 | 0.85 | PDE5A (0.63) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL11368836 | 0.83 | KDM4E (0.70) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL1483159 | 0.83 | KDM4E (0.48) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL10085609 | 0.82 | KDM4E (0.64) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3164011 | 0.82 | KDM4E (1.00) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL31311065 | 0.82 | KDM4E (1.00) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| Water SCHEMBL10826229 | 0.82 | RHEB (0.61) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL27312758 | 0.81 | KDM4E (0.57) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3698974 | 0.81 | RAB9A (0.75) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119675-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| US-8119675-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| US-20100016372-A1 | Benzimidazole Derivatives | MERCK PATENT GMBH (DE) | 2010-01-21 | — | — | US | disclosed |
| US-20100016372-A1 | Benzimidazole Derivatives | MERCK PATENT GMBH (DE) | 2010-01-21 | — | — | US | disclosed |
| WO-2008101586-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | WO | disclosed |
| US-20030104473-A1 | Common ligand mimics: benzimidazoles | TRIAD THERAPEUTICS, INC. | 2003-06-05 | — | — | US | disclosed |
| US-4623379-A | Plant growth and development modification using 2-(2-oxycarbonylphenyl)benzimidazole derivatives | FMC CORPORATION (US) | 1986-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030104473-A1 | Common ligand mimics: benzimidazoles | BID, LIFR, FGFR3 | KDM4E 2634/4885RAB9A 4667/4885ALDH1A1 1847/4885 |
| US-20100016372-A1 | Benzimidazole Derivatives | GPR119, GLP1R, H1-3 | KDM4E 1159/4885RAB9A 484/4885ALDH1A1 1591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.