SCHEMBL25706

SCHEMBL25706

COC(=O)C#CC(=O)OC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
TSHR P16473 3/20 0.37
HCAR2 Q8TDS4 2/20 0.37
KEAP1 Q14145 1/20 0.37
NFE2L2 Q16236 1/20 0.37
HSD17B10 Q99714 1/20 0.33
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PGK1 P00558 1/20 0.30
GABRP O00591 1/20 0.30
GABRD O14764 1/20 0.30
GABRA1 P14867 1/20 0.30
GABRB1 P18505 1/20 0.30
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1899467 0.87
SCHEMBL10962562 0.87 ALDH1A1 (0.35) ALDH1A1TSHRHCAR2KEAP1NFE2L2
SCHEMBL11351014 0.87 ALDH1A1 (0.35) ALDH1A1TSHRHCAR2KEAP1NFE2L2
SCHEMBL10136741 0.87
SCHEMBL2939248 0.86 ALDH1A1 (0.39) ALDH1A1TSHRHCAR2KEAP1NFE2L2
SCHEMBL27905777 0.85
SCHEMBL12174598 0.85 ALDH1A1 (0.33) ALDH1A1NPSR1
SCHEMBL7146408 0.85
SCHEMBL14215889 0.83
SCHEMBL797109 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4162 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026105155-A1 TRICYCLIC COMPOUND FOR BREAST AND OVARIAN CANCER TREATMENT COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2026-05-21 WO claimed
CN-122042169-A Lightweight spliced wide bridge vibration monitoring system for intelligent perception of cooperative working performance 沧州交通发展(集团)有限责任公司 2026-05-15 CN claimed
CN-122010829-A Method for preparing 2-aminopyridine compounds based on dearomatization-aromatization strategy 浙江师范大学 2026-05-12 CN claimed
WO-2026086923-A1 PREPARATION METHOD FOR OLIGONUCLEOTIDE ANALOG 福建盛迪医药有限公司 2026-04-30 WO claimed
US-20260098176-A1 COATING FILM COMPOSITION HAVING HEAT INSULATION AND COATED METAL PLATE USING SAME POSCO CO., LTD (KR) 2026-04-09 US claimed
US-20260077570-A1 UNCONSTRAINED VIBRATION DAMPING METAL SHEET WITH FOAM PORES AND METHOD FOR MANUFACTURING SAME POSCO CO., LTD. (KR) 2026-03-19 US claimed
US-12508796-B2 Unconstrained vibration damping metal sheet with foam pores and method for manufacturing same POSCO CO., LTD (KR) 2025-12-30 US claimed
US-20250382419-A1 DISULFIDATED POLYMERS AND METHODS OF PREPARATION UNIV COLORADO REGENTS (US) 2025-12-18 US claimed
EP-4592365-A1 COATING FILM COMPOSITION HAVING HEAT INSULATION AND COATED METAL PLATE USING SAME POSCO Co., Ltd (KR) 2025-07-30 EP claimed
US-12358943-B1 Method of synthesizing testosterone-based thiazolidinone derivatives IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) 2025-07-15 US claimed
US-4798900-A Producing bis(alicyclic) thioethers ETHYL CORPORATION (US) 1989-01-17 US claimed
US-4600784-A High pressure synthesis of substituted tetrathiafulvalenes KOPPERS COMPANY, INC. (US) 1986-07-15 US claimed
US-4465845-A High pressure synthesis of sulfur-selenium fulvalenes KOPPERS COMPANY, INC. (US) 1984-08-14 US claimed
EP-0021422-B1 GAS SEPARATING MEMBER KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 1984-01-11 EP claimed
US-4410338-A FORMING POLYMER FILM ON SUBSTRATE BY PLASMA POLYMERIZATION KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 1983-10-18 US claimed
US-4402875-A Substituted teraselenafulvalenes and high pressure synthesis thereof KOPPERS COMPANY, INC. (US) 1983-09-06 US claimed
US-4347346-A DIALKYLACETYLENEDICARBOXYITE TO PREVENT PREMATURE GELATION GENERAL ELECTRIC COMPANY (US) 1982-08-31 US claimed
US-4340710-A ETHYLENICALLY UNSATURATED ISOCYANURATE AND DIALKYL ACETYLENEDICARBOXYLATE STABILIZERS TO INHIBIT PREMATURE GELATION GENERAL ELECTRIC COMPANY (US) 1982-07-20 US claimed
EP-0021422-A1 Gas separating member KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 1981-01-07 EP claimed
US-4070259-A DIELS-ALDER REACTION PRODUCT, PAINTS, VARNISHES, INKS U C B, SOCIETE ANONYME (BE) 1978-01-24 US claimed