Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GAPDH | P04406 | 1/20 | 0.33 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574514 | 0.92 | ALDH1A1 (0.36) | ALDH1A1KMT2AMEN1HSD17B10MAPT | |
| SCHEMBL2530592 | 0.89 | RAB9A (0.43) | ALDH1A1KMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL2575481 | 0.88 | CRBN (0.45) | CRBNALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2535656 | 0.84 | ALDH1A1 (0.40) | CRBNALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2527478 | 0.81 | MEN1 (0.39) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL2530178 | 0.80 | NPC1 (0.40) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL2531679 | 0.80 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL2574768 | 0.79 | MAPT (0.40) | CRBNALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2533556 | 0.78 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL2535710 | 0.78 | PTPN1 (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558449-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011128251-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-20 | — | — | WO | disclosed |