SCHEMBL25715499

SCHEMBL25715499

CCCCOCC1CCNC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.46
CHRM1 P11229 2/20 0.41
CHRM2 P08172 1/20 0.41
CHRNB2 P17787 1/20 0.41
CHRM3 P20309 1/20 0.41
CHRNA4 P43681 1/20 0.41
SLC6A2 P23975 3/20 0.41
SLC6A4 P31645 3/20 0.41
SLC6A3 Q01959 1/20 0.41
TDP1 Q9NUW8 2/20 0.39
ALDH1A1 P00352 1/20 0.39
GNAO1 P09471 2/20 0.39
GNAI3 P08754 1/20 0.39
GNAI1 P63096 1/20 0.39
SLC6A1 P30531 2/20 0.37
GABRA5 P31644 2/20 0.37
GABRB2 P47870 2/20 0.37
SLC6A12 P48065 2/20 0.37
SLC6A11 P48066 2/20 0.37
SLC6A13 Q9NSD5 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13700362 1.00 SMN1; SMN2 (0.46) SMN1; SMN2CHRM1CHRM2CHRNB2CHRM3
SCHEMBL20017937 0.93 ALDH1A1 (0.49) SMN1; SMN2CHRM1CHRM2CHRNB2CHRM3
SCHEMBL13610209 0.93 ALDH1A1 (0.49) SMN1; SMN2CHRM1CHRM2CHRNB2CHRM3
SCHEMBL15108742 0.90 CHRNB2 (0.42) SMN1; SMN2CHRM1CHRM2CHRNB2CHRM3
SCHEMBL17706204 0.90 CHRNB2 (0.42) SMN1; SMN2CHRM1CHRM2CHRNB2CHRM3
SCHEMBL19959091 0.89 CHRNB2 (0.43) SMN1; SMN2CHRM1CHRM2CHRNB2CHRM3
SCHEMBL14395367 0.88 SMN1; SMN2 (0.48) SMN1; SMN2CHRM1SLC6A2SLC6A4TDP1
SCHEMBL19833463 0.84 ALDH1A1 (0.41) TDP1ALDH1A1GNAO1GNAI3GNAI1
SCHEMBL16181646 0.84 ALDH1A1 (0.41) TDP1ALDH1A1GNAO1GNAI3GNAI1
SCHEMBL13610211 0.82 ALDH1A1 (0.46) SMN1; SMN2CHRNB2CHRNA4TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3436446-B1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-06-07 EP disclosed