Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.38 |
| ▸ | FLT3 | P36888 | 11/20 | 0.37 |
| ▸ | FLT1 | P17948 | 10/20 | 0.37 |
| ▸ | FLT4 | P35916 | 10/20 | 0.37 |
| ▸ | KIT | P10721 | 9/20 | 0.37 |
| ▸ | CSF1R | P07333 | 9/20 | 0.37 |
| ▸ | LYN | P07948 | 9/20 | 0.37 |
| ▸ | SRC | P12931 | 8/20 | 0.37 |
| ▸ | BLK | P51451 | 8/20 | 0.37 |
| ▸ | LCK | P06239 | 8/20 | 0.37 |
| ▸ | FYN | P06241 | 6/20 | 0.37 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | CDK1 | P06493 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | PRKACA | P17612 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25718339 | 0.85 | KDR (0.44) | KDRFLT3FLT1FLT4KIT | |
| SCHEMBL25716849 | 0.76 | KIT (0.44) | KDRFLT3FLT1FLT4KIT | |
| SCHEMBL25715071 | 0.76 | BTK (0.49) | KDRFLT3FLT1FLT4KIT | |
| SCHEMBL25716316 | 0.74 | EPHB4 (0.40) | KDRFLT3FLT1FLT4KIT | |
| SCHEMBL25715151 | 0.71 | BTK (0.40) | KDRFLT3FLT1FLT4KIT | |
| SCHEMBL25715301 | 0.68 | KDR (0.38) | KDRFLT3FLT1FLT4KIT | |
| SCHEMBL22676401 | 0.64 | FGFR1 (0.49) | FLT3BLKBTKFGFR1RET | |
| SCHEMBL22676221 | 0.64 | FGFR1 (0.60) | KDRFLT3KITBLKBTK | |
| SCHEMBL30303438 | 0.64 | FGFR1 (0.49) | FLT3BLKBTKFGFR1RET | |
| SCHEMBL30303765 | 0.64 | FGFR1 (0.60) | KDRFLT3KITBLKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104035-A1 | SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 英矽智能科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |