Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.82 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.82 |
| ▸ | PDGFRB | P09619 | 14/20 | 0.82 |
| ▸ | RET | P07949 | 3/20 | 0.82 |
| ▸ | FLT3 | P36888 | 3/20 | 0.82 |
| ▸ | AURKA | O14965 | 2/20 | 0.82 |
| ▸ | FLT1 | P17948 | 2/20 | 0.82 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.82 |
| ▸ | STK3 | Q13188 | 2/20 | 0.82 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.82 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.82 |
| ▸ | GAK | O14976 | 1/20 | 0.82 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.82 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.82 |
| ▸ | LATS1 | O95835 | 1/20 | 0.82 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.82 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.82 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.82 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.82 |
| ▸ | STK4 | Q13043 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orantinib SCHEMBL134661 | 0.90 | FGFR1 (1.00) | KDRFGFR1PDGFRBRETFLT3 | |
| Orantinib SCHEMBL134662 | 0.90 | FGFR1 (1.00) | KDRFGFR1PDGFRBRETFLT3 | |
| Orantinib SCHEMBL29354645 | 0.90 | FGFR1 (1.00) | KDRFGFR1PDGFRBRETFLT3 | |
| Orantinib SCHEMBL900355 | 0.90 | FGFR1 (1.00) | KDRFGFR1PDGFRBRETFLT3 | |
| SCHEMBL12020869 | 0.88 | KDR (0.84) | KDRFGFR1PDGFRBRETFLT3 | |
| SCHEMBL16366587 | 0.85 | KDR (0.76) | KDRFGFR1PDGFRBRETFLT3 | |
| SCHEMBL13497857 | 0.85 | KDR (0.79) | KDRFGFR1PDGFRBRETFLT3 | |
| SCHEMBL26023377 | 0.85 | KDR (0.79) | KDRFGFR1PDGFRBRETFLT3 | |
| SCHEMBL12596436 | 0.84 | KDR (0.74) | KDRFGFR1PDGFRBRETFLT3 | |
| SCHEMBL16366048 | 0.84 | KDR (0.74) | KDRFGFR1PDGFRBRETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230181528-A1 | COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA | THE BROAD INSTITUTE, INC. (US) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230181528-A1 | COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA | VPS4B, ATG4A, ATG4B | KDR 4203/4885FGFR1 4308/4885PDGFRB 3933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.