Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQOR | Q9Y6N5 | 4/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25731600 | 0.84 | TGFBR1 (0.54) | TGFBR1MAPK14KMT2APDE10ARAB9A | |
| SCHEMBL21051591 | 0.82 | ESR2 (0.41) | TGFBR1MAPK14KMT2APDE10APAK1 | |
| Ammonia Solution, Strong SCHEMBL28862518 | 0.82 | MAPK14 (0.43) | TGFBR1MAPK14KMT2APDE10ARAB9A | |
| SCHEMBL25731603 | 0.82 | CYP11B1 (0.47) | PDE10AGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL25731622 | 0.82 | JMJD6 (0.45) | SQORTGFBR1MAPK14KMT2ARAB9A | |
| SCHEMBL25731646 | 0.81 | SCN9A (0.39) | TGFBR1MAPK14KMT2APDE10ASCN9A | |
| SCHEMBL25731605 | 0.80 | F2RL3 (0.44) | TGFBR1MAPK14PAK1 | |
| SCHEMBL174113 | 0.80 | RXRA (0.44) | PAK1 | |
| SCHEMBL28862516 | 0.78 | PDE10A (0.40) | TGFBR1MAPK14KMT2APDE10APAK1 | |
| SCHEMBL25731639 | 0.77 | BRD4 (0.43) | SQORKMT2AMAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107552-A2 | PURINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |