Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.55 |
| ▸ | MTOR | P42345 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30986787 | 1.00 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CGMTORKDM4E | |
| SCHEMBL25270780 | 0.90 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL30455857 | 0.84 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CGMTORKDM4E | |
| SCHEMBL25225255 | 0.84 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CGMTORKDM4E | |
| SCHEMBL25226288 | 0.83 | GAK (0.44) | PIK3CAPIK3CDPIK3CGMTORKDM4E | |
| SCHEMBL25228692 | 0.82 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CGMTORKDM4E | |
| SCHEMBL24470032 | 0.81 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL24470255 | 0.79 | KDM4E (0.45) | PIK3CAMTORKDM4ENPC1ALDH1A1 | |
| SCHEMBL25230973 | 0.74 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL30456439 | 0.74 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | YUMANITY THERAPEUTICS, INC. | 2024-06-27 | — | — | US | disclosed |
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | YUMANITY THERAPEUTICS, INC. | 2024-06-27 | — | — | US | disclosed |
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | PNPO, DPYD, PYGB | PIK3CA 3369/4885PIK3CD 3769/4885PIK3CG 3429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.