Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.81 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25193575 | 0.90 | KCNN3 (1.00) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL25726154 | 0.88 | KCNN3 (0.63) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL30421423 | 0.82 | KCNN3 (0.67) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL19690859 | 0.80 | KCNN3 (0.71) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL4212697 | 0.78 | KCNN3 (0.80) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL4212917 | 0.75 | TP53 (0.80) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL25187037 | 0.75 | KCNN3 (0.73) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL30421866 | 0.75 | KCNN3 (0.73) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL2448726 | 0.74 | TP53 (0.65) | KCNN3POLBTP53MAPTLMNA | |
| SCHEMBL14027528 | 0.74 | CYP1A2 (0.71) | KCNN3MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159500-A1 | SK CHANNEL POSITIVE ALLOSTERIC MODULATORS | CHAPMAN UNIVERSITY | 2023-05-25 | — | — | US | disclosed |
| US-20230159500-A1 | SK CHANNEL POSITIVE ALLOSTERIC MODULATORS | CHAPMAN UNIVERSITY | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159500-A1 | SK CHANNEL POSITIVE ALLOSTERIC MODULATORS | KCNN1, KCNN4, KCNN2 | KCNN3 4/4885POLB 3617/4885TP53 4111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.