Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 13/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20438228 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM2BGBA1CHRM5ADRA2C | |
| SCHEMBL17873962 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM2BGBA1CHRM5ADRA2C | |
| SCHEMBL2446419 | 0.73 | — | — | |
| SCHEMBL13905846 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM2BGBA1CHRM5ADRA2C | |
| SCHEMBL13905729 | 0.69 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM2BGBA1CHRM5ADRA2C | |
| SCHEMBL13045996 | 0.69 | BCHE (0.43) | SMN1; SMN2BCHE | |
| SCHEMBL12065915 | 0.69 | — | — | |
| SCHEMBL22359134 | 0.68 | BCHE (0.45) | SMN1; SMN2BCHEGBA1 | |
| SCHEMBL12116519 | 0.68 | HDAC8 (0.56) | SMN1; SMN2 | |
| SCHEMBL4678458 | 0.66 | PLG (0.45) | SMN1; SMN2KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237411-B1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |