Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 14/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22358960 | 0.83 | GBA1 (0.49) | GBA1KDM2BACHE | |
| SCHEMBL24003650 | 0.82 | KDM2B (0.35) | SMN1; SMN2KDM2B | |
| SCHEMBL17873962 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2GBA1KDM2BCHRM5ADRA2C | |
| SCHEMBL13905846 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2GBA1KDM2BCHRM5ADRA2C | |
| SCHEMBL25728779 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2GBA1KDM2BCHRM5ADRA2C | |
| SCHEMBL27274598 | 0.76 | CHRM5 (0.43) | SMN1; SMN2GBA1KDM2BCHRM5ADRA2C | |
| SCHEMBL13905729 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2GBA1KDM2BCHRM5ADRA2C | |
| SCHEMBL13136048 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2CHRM5ADRA2CACHE | |
| SCHEMBL4678458 | 0.72 | PLG (0.45) | SMN1; SMN2KDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL25512557 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180214419-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180214419-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF INCREASING CFTR ACTIVITY | CFTR, ABCB4, SCNN1B | SMN1; SMN2 3701/4885GBA1 83/4885KDM2B 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.