Sugi Predict

Sugi Predict / Compounds / SCHEMBL2573248

SCHEMBL2573248

SCHEMBL2573248

Nn1ccc2ncc(Br)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 2/20 0.37
▸ HTT P42858 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ DYRK1A Q13627 4/20 0.36
▸ KDM4E B2RXH2 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ GLA P06280 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ MET P08581 1/20 0.33
▸ CDC7 O00311 2/20 0.30
▸ CDK2 P24941 1/20 0.30
▸ MAP3K14 Q99558 1/20 0.30
▸ CHEK1 O14757 1/20 0.30
▸ AURKA O14965 1/20 0.30
▸ DAPK3 O43293 1/20 0.30
▸ JAK2 O60674 1/20 0.30
▸ MAP4K4 O95819 1/20 0.30
▸ PAK4 O96013 1/20 0.30
▸ ABL1 P00519 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2371256 0.77 HSD17B10 (0.44) HSD17B10HTTKMT2ADYRK1AKDM4E
SCHEMBL2579990 0.77 HSD17B10 (0.37) HSD17B10HTTKMT2ADYRK1AKDM4E
SCHEMBL16302854 0.77 CYP1A2 (0.41) HSD17B10KDM4EALDH1A1GLAGAA
SCHEMBL23125736 0.74 HSD17B10 (0.35) HSD17B10HTTKMT2ADYRK1AMET
SCHEMBL24659824 0.73 HSD17B10 (0.34) HSD17B10DYRK1AKDM4EALDH1A1MET
SCHEMBL12291376 0.73 GRIN2B (0.40) HSD17B10
SCHEMBL16302863 0.72 HSD17B10 (0.39) HSD17B10HTTKMT2ADYRK1AMET
SCHEMBL15272159 0.72 RPS6KA5 (0.59) HSD17B10ALDH1A1CDC7CDK2
SCHEMBL26683839 0.72 ENPP3 (0.39) HSD17B10KDM4EALDH1A1FGFR1DYRK1B
SCHEMBL1336229 0.70 HSD17B10 (0.36) HSD17B10DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8912330-B2 Azaindole derivatives as kinase inhibitors ARIAD PHARMACEUTICALS, INC. (US) 2014-12-16 — — US disclosed
US-8912330-B2 Azaindole derivatives as kinase inhibitors ARIAD PHARMACEUTICALS, INC. (US) 2014-12-16 — — US disclosed
US-8912330-B2 Azaindole derivatives as kinase inhibitors ARIAD PHARMACEUTICALS, INC. (US) 2014-12-16 — — US disclosed
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2011-12-01 — — US disclosed
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2011-12-01 — — US disclosed
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2011-12-01 — — US disclosed
EP-2381777-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD Pharmaceuticals, Inc (US) 2011-11-02 — — EP disclosed
WO-2010068292-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2010-06-17 — — WO disclosed
WO-2010068292-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2010-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ABL1, CDKN1A, MAP3K13 HSD17B10 3069/4885HTT 4392/4885KMT2A 408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.