Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.53 |
| ▸ | YES1 | P07947 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CSK | P41240 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230249 | 0.81 | SRC (0.77) | SRCYES1PDGFRBEPHB4BRAF | |
| SCHEMBL5501154 | 0.80 | SRC (0.69) | SRCYES1PDGFRBEPHB4BRAF | |
| SCHEMBL2580765 | 0.79 | SRC (0.46) | SRCYES1PDGFRBEPHB4BRAF | |
| SCHEMBL28931702 | 0.77 | EGFR (0.46) | YES1PDGFRBEPHB4EGFRCYP2D6 | |
| SCHEMBL226165 | 0.76 | SRC (0.55) | SRCYES1PDGFRBEPHB4BRAF | |
| SCHEMBL226164 | 0.76 | SRC (0.55) | SRCYES1PDGFRBEPHB4BRAF | |
| SCHEMBL3965200 | 0.76 | AXL (0.41) | SRCYES1PDGFRBEPHB4KDR | |
| SCHEMBL3969743 | 0.74 | AXL (0.42) | YES1PDGFRBEPHB4 | |
| SCHEMBL29205086 | 0.74 | JAK2 (0.48) | YES1PDGFRBEPHB4EGFRKDR | |
| SCHEMBL3964520 | 0.74 | AXL (0.41) | YES1PDGFRBEPHB4CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2381943-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | Fovea Pharmaceuticals (FR) | 2011-11-02 | — | — | EP | disclosed |