Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SDCBP | O00560 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25742181 | 0.79 | LMNA (0.39) | LMNATHRBMEN1KMT2AREN | |
| SCHEMBL25742303 | 0.77 | LMNA (0.36) | LMNATHRBMEN1KMT2AREN | |
| SCHEMBL25742155 | 0.76 | LMNA (0.42) | LMNATHRBMEN1KMT2AALOX15 | |
| SCHEMBL24701178 | 0.76 | LMNA (0.43) | LMNATHRBMEN1KMT2AMAPT | |
| SCHEMBL25741822 | 0.74 | LMNA (0.37) | LMNATHRBMEN1KMT2AALOX15 | |
| SCHEMBL23986739 | 0.74 | LMNA (0.41) | LMNATHRBMEN1KMT2AALOX15 | |
| SCHEMBL25467046 | 0.73 | LMNA (0.46) | LMNATHRBMEN1KMT2AALOX15 | |
| SCHEMBL27318763 | 0.73 | LMNA (0.46) | LMNATHRBMEN1KMT2AALOX15 | |
| SCHEMBL25741162 | 0.73 | MAPK1 (0.40) | LMNATHRBMEN1KMT2AREN | |
| SCHEMBL23729223 | 0.72 | LMNA (0.44) | LMNATHRBMEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122581-A2 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |