SCHEMBL24701178

SCHEMBL24701178

CCCC(C(=O)NC=O)N1Cc2cc(CNC(=O)Nc3ccccc3NC)ccc2C1=O

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.43
MAPT P10636 4/20 0.40
THRB P10828 2/20 0.40
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
POLB P06746 1/20 0.38
TP53 P04637 1/20 0.38
ALDH1A1 P00352 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25742155 0.80 LMNA (0.42) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL23986739 0.78 LMNA (0.41) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL25467046 0.77 LMNA (0.46) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL27318763 0.77 LMNA (0.46) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL22199073 0.76 CYP2C19 (0.52) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL23129312 0.76 LMNA (0.42) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL23729223 0.76 LMNA (0.44) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL25741065 0.76 LMNA (0.40) LMNAMAPTTHRBMEN1KMT2A
SCHEMBL24822634 0.76 SDCBP (0.37) LMNATHRBMEN1KMT2ATP53
SCHEMBL23129018 0.75 LMNA (0.43) LMNAMAPTTHRBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022254377-A1 NEODEGRADER-ANTI-CD33 ANTIBODY CONJUGATES ORUM THERAPEUTICS, INC. (KR) 2022-12-08 WO disclosed