Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263689 | 0.87 | LMNA (0.56) | LMNAALDH1A1MAPK1HSD17B10KDM4E | |
| SCHEMBL10710003 | 0.82 | AKR1C4 (0.56) | LMNAALDH1A1MAPK1CA12CA1 | |
| SCHEMBL3898096 | 0.80 | LMNA (0.50) | LMNAALDH1A1MAPK1HSD17B10KDM4E | |
| SCHEMBL27719001 | 0.79 | LMNA (0.49) | LMNAALDH1A1MAPK1HSD17B10KDM4E | |
| SCHEMBL17202484 | 0.76 | LMNA (0.64) | LMNAALDH1A1CA12CA1CA2 | |
| SCHEMBL1259483 | 0.76 | LMNA (0.59) | LMNAALDH1A1MAPK1CA12CA1 | |
| SCHEMBL286633 | 0.75 | MYC (0.56) | ALDH1A1CA12CA1CA2CA3 | |
| SCHEMBL2226763 | 0.75 | AKR1C3 (0.61) | LMNAALDH1A1HSD17B10KDM4EMEN1 | |
| SCHEMBL29454359 | 0.75 | MYC (0.56) | ALDH1A1CA12CA1CA2CA3 | |
| SCHEMBL21609786 | 0.73 | AKR1C4 (0.44) | ALDH1A1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |