Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.69 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956658 | 0.82 | GAA (1.00) | GAAPRKDCHPGDALDH1A1MAPT | |
| SCHEMBL26626649 | 0.75 | GAA (0.60) | GAAPRKDCHPGDALDH1A1MAPT | |
| Formamide SCHEMBL29160387 | 0.74 | GAA (0.47) | GAAPRKDCHPGDALDH1A1MAPT | |
| SCHEMBL11357473 | 0.73 | KMT2A (0.56) | GAAHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL4544196 | 0.72 | PRKDC (1.00) | GAAPRKDC | |
| SCHEMBL6132105 | 0.72 | PIK3CB (0.55) | PRKDCSMN1; SMN2 | |
| SCHEMBL18412791 | 0.72 | PRKDC (0.52) | GAAPRKDCHPGDALDH1A1MAPT | |
| SCHEMBL23780891 | 0.72 | GAA (0.41) | GAAHPGDALDH1A1MAPTALOX12 | |
| SCHEMBL3955093 | 0.70 | ALDH1A1 (0.65) | GAAALDH1A1MAPTPOLBGFER | |
| SCHEMBL7016317 | 0.70 | KDM4E (0.51) | GAAHPGDALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2557923-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | Curis, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130628-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |