SCHEMBL257515

SCHEMBL257515

CCCC(CC)c1ccc(C(=O)c2ccc(C)c(Cl)c2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
SLC6A4 P31645 5/20 0.40
SLC6A3 Q01959 5/20 0.40
SLC6A2 P23975 4/20 0.40
TAS1R3 Q7RTX0 4/20 0.40
TAS1R1 Q7RTX1 4/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
CHRNA1 P02708 1/20 0.40
CHRNG P07510 1/20 0.40
CHRNB1 P11230 1/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA4 P43681 1/20 0.40
CHRND Q07001 1/20 0.40
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26382139 0.81 ALDH1A1 (0.53) SLC6A4SLC6A3SLC6A2HDAC8HDAC6
SCHEMBL20459002 0.81 CYP3A4 (0.38) AGTR1GAAMAPTSLC6A4SLC6A3
SCHEMBL28787077 0.78 ALDH1A1 (0.50) MAPTHDAC8HDAC6HTTSMN1; SMN2
SCHEMBL2924706 0.77 HPGD (0.54) AGTR1MAPTSLC6A4SLC6A3SLC6A2
SCHEMBL15100551 0.75 MAPT (0.63) AGTR1GAAMAPTSLC6A4SLC6A3
SCHEMBL15100942 0.74 SRD5A2 (0.53) MAPTSLC6A4SLC6A3SLC6A2CHRNA1
SCHEMBL257653 0.74 ALDH1A1 (0.61) AGTR1MAPTSLC6A4SLC6A3SLC6A2
SCHEMBL26841012 0.74 HDAC8 (0.66) MAPTSLC6A3SLC6A2HDAC8HDAC6
SCHEMBL823013 0.73 HDAC8 (0.56) HDAC8HDAC6HTTSMN1; SMN2SRD5A2
SCHEMBL13176761 0.73 ATM (0.55) AGTR1GAAMAPTHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012029942-A1 CYCLIC AMIDE DERIVATIVE 大日本住友製薬株式会社 (JP) 2012-03-08 WO disclosed