SCHEMBL257517

SCHEMBL257517

Nc1ccc(-n2ccc3cc(N)ccc32)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.55
BRPF1 P55201 2/20 0.50
KCNH2 Q12809 1/20 0.46
BIRC5 O15392 1/20 0.43
ALDH1A1 P00352 2/20 0.42
ALOX15 P16050 1/20 0.42
HTT P42858 1/20 0.42
ATM Q13315 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.40
PLA2G4A P47712 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29755944 0.98 PRKCI (0.57) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL16862053 0.89 BIRC5 (0.59) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL30364829 0.89 KCNH2 (0.60) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL4572982 0.89 KCNH2 (0.60) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL14513875 0.89 PRKCI (0.53) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL15712437 0.89 SMN1; SMN2 (0.55) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL16862145 0.86 KCNH2 (0.54) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL30241476 0.86 KCNH2 (0.54) PRKCIBRPF1KCNH2BIRC5ALDH1A1
SCHEMBL31735405 0.85 PRKCI (0.49) PRKCIBRPF1KCNH2MAPTFGFR1
SCHEMBL720541 0.85 PRKCI (0.49) PRKCIBRPF1KCNH2MAPTFGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3125033-B1 LIQUID CRYSTAL DISPLAY DEVICE JNC CORP (JP) 2021-06-02 EP disclosed
US-10968392-B2 Liquid crystal aligning agent for photoalignment, liquid crystal alignment film and liquid crystal display device using it, and diamine and polymer JNC CORPORATION (JP) 2021-04-06 US disclosed
US-20200332193-A1 LIQUID CRYSTAL ELEMENT USED FOR PHASE CONTROL OF ELECTROMAGNETIC WAVE SIGNAL JNC CORPORATION (JP) 2020-10-22 US disclosed
US-10782566-B2 Liquid crystal display device JNC CORPORATION (JP) 2020-09-22 US disclosed
EP-3179303-B1 LIQUID CRYSTAL DISPLAY ELEMENT JNC CORP (JP) 2020-04-01 EP disclosed
CN-105367560-B Tetracarboxylic dianhydride, polymer, aligning agent for liquid crystal, liquid crystal orientation film and liquid crystal display element containing triazole 捷恩智株式会社 2019-11-05 CN disclosed
US-10435627-B2 Liquid crystal display device JNC CORPORATION (JP) 2019-10-08 US disclosed
EP-3133136-B1 LIQUID CRYSTAL DISPLAY DEVICE JNC CORP (JP) 2019-08-07 EP disclosed
EP-3163368-B1 LIQUID CRYSTAL DISPLAY ELEMENT JNC CORP (JP) 2019-06-26 EP disclosed
US-20190127643-A1 LIQUID CRYSTAL ALIGNING AGENT FOR PHOTOALIGNMENT, LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY DEVICE USING IT, AND DIAMINE AND POLYMER JNC CORPORATION (JP) 2019-05-02 US disclosed
US-20150105503-A1 LIQUID CRYSTAL ALIGNING AGENTS FOR FORMING PHOTO-ALIGNING LIQUID CRYSTAL ALIGNMENT LAYERS, LIQUID CRYSTAL ALIGNMENT LAYERS AND LIQUID CRYSTAL DISPLAY DEVICES USING THE SAME JNC PETROCHEMICAL CORPORATION (JP) 2015-04-16 US disclosed
US-20150105503-A1 LIQUID CRYSTAL ALIGNING AGENTS FOR FORMING PHOTO-ALIGNING LIQUID CRYSTAL ALIGNMENT LAYERS, LIQUID CRYSTAL ALIGNMENT LAYERS AND LIQUID CRYSTAL DISPLAY DEVICES USING THE SAME JNC PETROCHEMICAL CORPORATION (JP) 2015-04-16 US disclosed
CN-104058993-A Photosensitive Diamines, Polyamide Acid And Derivatives Thereof, Liquid Crystal Aligning Agents, Liquid Crystal Alignment Films And Liquid Crystal Display Devices JNC PETROCHEMICAL CORP 2014-09-24 CN disclosed
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-08-28 US disclosed
WO-2013161569-A1 LIQUID-CRYSTAL-ORIENTING AGENT FOR FORMING LIQUID-CRYSTAL-ORIENTED FILM FOR PHOTOALIGNMENT, LIQUID-CRYSTAL-ORIENTED FILM, AND LIQUID-CRYSTAL DISPLAY ELEMENT USING LIQUID-CRYSTAL-ORIENTED FILM JNC株式会社 (JP) 2013-10-31 WO disclosed
CN-103282034-A Use of hematopoietic growth factor mimetics LIGAND PHARM INC 2013-09-04 CN disclosed
CN-103180294-A Diamine, polyimide precursor, polyimide, liquid-crystal alignment material, liquid-crystal alignment film, and liquid-crystal display element NISSAN CHEMICAL IND LTD 2013-06-26 CN disclosed
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2012-11-22 US disclosed
CN-102656141-A Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARM INC 2012-09-05 CN disclosed
WO-2012029763-A1 DIAMINE, POLYIMIDE PRECURSOR, POLYIMIDE, LIQUID-CRYSTAL ALIGNMENT MATERIAL, LIQUID-CRYSTAL ALIGNMENT FILM, AND LIQUID-CRYSTAL DISPLAY ELEMENT 日産化学工業株式会社 (JP) 2012-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10968392-B2 Liquid crystal aligning agent for photoalignment, liquid crystal alignment film and liquid crystal display device using it, and diamine and polymer DDT, DCLRE1A, DVL1 PRKCI 1660/4885BRPF1 3465/4885KCNH2 3072/4885
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS HGF, EPOR, MPL PRKCI 2155/4885BRPF1 418/4885KCNH2 4861/4885
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF PRKCI 2706/4885BRPF1 957/4885KCNH2 4762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.