Sugi Predict

Sugi Predict / Targets / DVL1

DVL1

Segment polarity protein dishevelled homolog DVL-1 · O14640 · DVL1 on Sugi Atlas →

583 patent compounds predicted against DVL1, 415 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3078012 SCHEMBL3078012 0.60 3/20
SCHEMBL1913466 SCHEMBL1913466 0.52 3/20
SCHEMBL4251120 SCHEMBL4251120 0.52 3/20
SCHEMBL29381538 SCHEMBL29381538 0.52 3/20
SCHEMBL29754378 SCHEMBL29754378 0.47 3/20
SCHEMBL29433961 SCHEMBL29433961 1.00 2/20
SCHEMBL10260354 SCHEMBL10260354 0.64 2/20
SCHEMBL10260434 SCHEMBL10260434 0.64 2/20
SCHEMBL15506804 SCHEMBL15506804 0.49 2/20
SCHEMBL10779581 SCHEMBL10779581 0.45 2/20
SCHEMBL4213492 SCHEMBL4213492 0.45 2/20
SCHEMBL10780432 SCHEMBL10780432 0.44 2/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL10784337) 0.44 2/20
SCHEMBL27343649 SCHEMBL27343649 0.44 2/20
Isopropyl Alcohol Isopropyl Alcohol (SCHEMBL11011590) 0.42 2/20
SCHEMBL20794421 SCHEMBL20794421 0.42 2/20
SCHEMBL13754925 SCHEMBL13754925 0.42 2/20
SCHEMBL20794764 SCHEMBL20794764 0.41 2/20
SCHEMBL12826058 SCHEMBL12826058 0.38 2/20
SCHEMBL14075194 SCHEMBL14075194 0.78 1/20

Clinical trials — most relevant to DVL1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment PHASE2/PHASE3RECRUITING
NG2 and DLL3 CAR-T Cells Targeting Melanoma PHASE1/PHASE2RECRUITING
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma PHASE2RECRUITING
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma PHASE1COMPLETED
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study nanCOMPLETED
Klotho _ LRP-6 _ Gastric Adenocarcinoma nanUNKNOWN
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins nanCOMPLETED
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury nanUNKNOWN
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma. nanRECRUITING
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia nanCOMPLETED
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs nanCOMPLETED
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science nanRECRUITING
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
CDH1 Germline Mutations in Lobular Breast Cancer nanCOMPLETED
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies nanRECRUITING
Epithelial Mesenchymal Transition and Periodontitis nanUNKNOWN
Influence of EMT on CTCs and Disease Progression in Prostate Cancer nanCOMPLETED
Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors nanNO_LONGER_AVAILABLE
Genetic Variants of Selected Genes in Colo-Rectal Cancer Patients. nanUNKNOWN
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Mapping Disease Pathways for Biliary Atresia nanRECRUITING
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy nanCOMPLETED
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls. nanUNKNOWN
Studying the Role of Circulating Tumor Cell Clusters in Patients With High-risk Early Breast Cancer, Study GALIA nanRECRUITING
The Activation of Hippo Pathway in Nasal Polyps nanUNKNOWN
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia nanUNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan nanENROLLING_BY_INVITATION
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DVL1 binder may also engage these)

ProteinNameSimilarity
Q9WVB9 — 1.000 Q9WVB9 →
P54792 — 1.000 P54792 →
P51141 — 1.000 P51141 →
Q05AS8 — 1.000 Q05AS8 →
Q5IS48 — 1.000 Q5IS48 →
Q60838 — 0.997 Q60838 →
O14641 — 0.996 O14641 →
P51142 — 0.996 P51142 →
Q61062 — 0.995 Q61062 →
DVL3 Segment polarity protein dishevelled homolog DVL-3 0.993 landscape →
B1WAP7 — 0.991 B1WAP7 →
Q6DKE2 — 0.988 Q6DKE2 →
Q80W04 — 0.987 Q80W04 →
Q4ACU6 — 0.986 Q4ACU6 →
Q9WV48 — 0.986 Q9WV48 →
P59281 — 0.985 P59281 →
D3YZU1 — 0.985 D3YZU1 →
Q9BYB0 — 0.984 Q9BYB0 →
Q9Y566 — 0.984 Q9Y566 →
Q9C0H9 — 0.984 Q9C0H9 →
P91621 — 0.983 P91621 →
O43439 — 0.982 O43439 →
Q7PQ25 — 0.982 Q7PQ25 →
Q9JLU4 — 0.982 Q9JLU4 →
PTPN21 Protein-tyrosine phosphatase D1 0.982 landscape →
Q69ZZ6 — 0.982 Q69ZZ6 →
Q9UQB3 — 0.981 Q9UQB3 →
Q9Y2L6 — 0.981 Q9Y2L6 →
Q95168 — 0.981 Q95168 →
Q66IV1 — 0.981 Q66IV1 →