Sugi Predict

Sugi Predict / Compounds / SCHEMBL2575194

SCHEMBL2575194

SCHEMBL2575194

Cn1cc(-c2cc(N)nc(-c3cnn(COCC[Si](C)(C)C)c3)n2)cn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CHEK1 O14757 1/20 0.34
▸ PIK3CD O00329 1/20 0.34
▸ PIK3CA P42336 1/20 0.34
▸ PIK3CB P42338 1/20 0.34
▸ PI4KA P42356 1/20 0.34
▸ PIK3CG P48736 1/20 0.34
▸ PI4KB Q9UBF8 1/20 0.34
▸ CSF1R P07333 2/20 0.34
▸ DGAT1 O75907 1/20 0.34
▸ KCNH2 Q12809 3/20 0.33
▸ LOXL2 Q9Y4K0 1/20 0.33
▸ FGFR1 P11362 1/20 0.33
▸ FGFR2 P21802 1/20 0.33
▸ FGFR4 P22455 1/20 0.33
▸ FGFR3 P22607 1/20 0.33
▸ KDR P35968 1/20 0.33
▸ FLT3 P36888 1/20 0.33
▸ FEN1 P39748 2/20 0.33
▸ CD38 P28907 1/20 0.33
▸ GRIN2B Q13224 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2564359 0.82 DGAT1 (0.34) PIK3CDPIK3CAPIK3CBPI4KAPIK3CG
SCHEMBL2568070 0.82 DGAT1 (0.32) PIK3CDPIK3CAPIK3CBPI4KAPIK3CG
SCHEMBL2573099 0.75 TNK2 (0.37) DGAT1ADORA2A
SCHEMBL3635220 0.74 KCNH2 (0.37) PIK3CDPIK3CAPIK3CBPI4KAPIK3CG
SCHEMBL2573190 0.73 TNK2 (0.38) DGAT1KDR
SCHEMBL18985815 0.73 PIK3CD (0.38) PIK3CDPIK3CAPIK3CBPI4KAPIK3CG
SCHEMBL24327356 0.73 FGFR3 (0.48) CHEK1PIK3CDPIK3CAPIK3CBPI4KA
SCHEMBL29601467 0.73 FGFR3 (0.48) CHEK1PIK3CDPIK3CAPIK3CBPI4KA
SCHEMBL14656027 0.71 PIK3CD (0.45) CHEK1PIK3CDPIK3CAPIK3CBPI4KA
SCHEMBL31074654 0.71 AXL (0.34) CHEK1PIK3CDPIK3CAPIK3CBPI4KA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2558468-B1 5, 7-SUBSTITUTED-IMIDAZO [1,2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES ARRAY BIOPHARMA INC (US) 2015-04-01 — — EP disclosed
US-8962596-B2 5,7-substituted-imidazo[1,2-C]pyrimidines as inhibitors of JAK kinases ARRAY BIOPHARMA INC. (US) 2015-02-24 — — US disclosed
US-20140228349-A1 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES ARRAY BIOPHARMA, INC. 2014-08-14 — — US disclosed
US-20130131039-A1 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES AS INHIBITORS OF JAK KINASES ARRAY BIOPHARMA INC. (US) 2013-05-23 — — US disclosed
EP-2558468-A1 5, 7-SUBSTITUTED-IMIDAZO [1, 2-C]PYRIMIDINES AS INHIBITORS OF JAK KINASES Array Biopharma, Inc. (US) 2013-02-20 — — EP disclosed
WO-2011130146-A1 5, 7-SUBSTITUTED-IMIDAZO [1, 2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES ARRAY BIOPHARMA INC. (US) 2011-10-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130131039-A1 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES AS INHIBITORS OF JAK KINASES JAK1, JAK3, JAK2 CHEK1 341/4885PIK3CD 159/4885PIK3CA 111/4885
US-20140228349-A1 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES JAK1, JAK3, JAK2 CHEK1 251/4885PIK3CD 345/4885PIK3CA 253/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.