Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2B | P41595 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572351 | 0.83 | HTR2A (0.41) | HTR2AHTR2CHTR2BGAABRD4 | |
| SCHEMBL2575403 | 0.83 | HTR2A (0.62) | HTR2AHTR2CHTR2BGAABRD4 | |
| SCHEMBL2562703 | 0.75 | MEN1 (0.40) | HTR2AHTR2CHTR2BGAABRD4 | |
| SCHEMBL2014604 | 0.74 | HTR2C (0.51) | HTR2AHTR2CHTR2BGAAOPRM1 | |
| SCHEMBL693673 | 0.74 | HTR2C (0.51) | HTR2AHTR2CHTR2BGAAOPRM1 | |
| SCHEMBL18686003 | 0.73 | GAA (0.40) | GAABRD4CREBBPEP300OPRM1 | |
| SCHEMBL18686018 | 0.73 | ALDH1A1 (0.53) | GAABRD4CREBBPRAB9AALDH1A1 | |
| SCHEMBL18686001 | 0.72 | EPHX2 (0.42) | GAABRD4CREBBPEP300OPRM1 | |
| SCHEMBL17748861 | 0.68 | GAA (0.64) | HTR2AHTR2CGAABRD4CREBBP | |
| SCHEMBL15389746 | 0.65 | HTT (0.42) | GAABRD4CREBBPRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |