Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15497032 | 0.88 | ALDH1A1 (0.46) | MAPTALDH1A1HTTHSD17B10CTSA | |
| SCHEMBL12525555 | 0.88 | ALDH1A1 (0.46) | MAPTALDH1A1HTTHSD17B10CTSA | |
| SCHEMBL12492506 | 0.87 | MAPT (0.40) | MAPTALDH1A1HTTKDM4ECTSA | |
| Hydrochloric Acid SCHEMBL29891870 | 0.87 | ALDH1A1 (0.45) | MAPTALDH1A1HTTHSD17B10CTSA | |
| Hydrochloric Acid SCHEMBL29115990 | 0.87 | ALDH1A1 (0.45) | MAPTALDH1A1HTTHSD17B10CTSA | |
| SCHEMBL24036692 | 0.85 | GAA (0.38) | MAPTALDH1A1HTTHSD17B10KDM4E | |
| SCHEMBL24036820 | 0.83 | CFTR (0.43) | MAPTKDM4ECTSAMC4R | |
| SCHEMBL24036573 | 0.83 | ALDH1A1 (0.39) | MAPTALDH1A1HTTPKMKDM4E | |
| SCHEMBL25753758 | 0.83 | ALDH1A1 (0.36) | MAPTALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL25752841 | 0.82 | MAPT (0.39) | MAPTHTTHSD17B10KDM4ECTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | UBE CORPORATION (JP) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | DHFR, DPYD, CYP2D6 | MAPT 3157/4885ALDH1A1 208/4885HTT 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.