Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 4/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.34 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.34 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.34 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30895047 | 1.00 | MAPK1 (0.39) | MAPK1NR3C1AAK1PIK3CAMTOR | |
| SCHEMBL25753440 | 0.93 | GSK3B (0.38) | PIK3CAMTORPIK3CGGSK3BDYRK1A | |
| SCHEMBL27199660 | 0.86 | MAPK1 (0.44) | MAPK1NR3C1PDE1APDE1BPDE1C | |
| SCHEMBL30895121 | 0.86 | GSK3B (0.36) | NR3C1PIK3CAMTORGSK3BDYRK1A | |
| SCHEMBL30860940 | 0.84 | RXRA (0.38) | ATRGSK3BDYRK1ABRD4LMNA | |
| SCHEMBL25756633 | 0.80 | GSK3B (0.40) | MAPK1PIK3CAPIK3CGATRGSK3B | |
| SCHEMBL30860930 | 0.80 | GSK3B (0.40) | MAPK1PIK3CAPIK3CGATRGSK3B | |
| SCHEMBL27199485 | 0.78 | BRD4 (0.38) | MAPK1PDE1APDE1BPDE1CBRD4 | |
| SCHEMBL30895136 | 0.77 | GSK3B (0.36) | PIK3CAPIK3CGATRGSK3BDYRK1A | |
| SCHEMBL31017447 | 0.77 | GSK3B (0.36) | PIK3CAPIK3CGATRGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118401516-A | TYK2 inhibitors, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-26 | — | — | CN | disclosed |
| WO-2023109954-A1 | TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2023-06-22 | — | — | WO | disclosed |