Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24036985 | 1.00 | KCNA5 (0.47) | KCNA5MEN1POLBKMT2ACTSA | |
| SCHEMBL30671348 | 0.90 | ALDH1A1 (0.39) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL29423266 | 0.90 | ALDH1A1 (0.39) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL22699241 | 0.90 | ALDH1A1 (0.39) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL22837965 | 0.90 | ALDH1A1 (0.39) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL20546555 | 0.88 | CYP26A1 (0.44) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL22691186 | 0.88 | CYP26A1 (0.44) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL22691188 | 0.88 | CYP26A1 (0.44) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL22691183 | 0.88 | CYP26A1 (0.44) | KCNA5CTSACYP26A1ALDH1A1MAPT | |
| SCHEMBL24036770 | 0.88 | POLB (0.35) | KCNA5MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | UBE CORPORATION (JP) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | DHFR, DPYD, CYP2D6 | KCNA5 1043/4885MEN1 431/4885POLB 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.