Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 16/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950358 | 0.93 | NLRP3 (0.57) | NLRP3KCNH2ORAI1 | |
| SCHEMBL25753970 | 0.90 | NLRP3 (0.55) | NLRP3THRBKCNH2ORAI1 | |
| SCHEMBL30040964 | 0.89 | NLRP3 (0.53) | NLRP3KCNH2ORAI1 | |
| SCHEMBL23950629 | 0.89 | NLRP3 (0.53) | NLRP3KCNH2ORAI1 | |
| SCHEMBL23950182 | 0.89 | NLRP3 (0.53) | NLRP3KCNH2 | |
| SCHEMBL23950218 | 0.86 | NLRP3 (0.53) | NLRP3THRB | |
| SCHEMBL23950542 | 0.85 | NLRP3 (0.55) | NLRP3THRBKCNH2 | |
| SCHEMBL23950615 | 0.85 | NLRP3 (0.55) | NLRP3THRBKCNH2 | |
| SCHEMBL23950612 | 0.85 | NLRP3 (0.55) | NLRP3ORAI1 | |
| SCHEMBL25753410 | 0.85 | NLRP3 (0.51) | NLRP3THRBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203044-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203044-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME | NLRP3, PYCARD, NLRP1 | NLRP3 1/4885THRB 2320/4885KCNH2 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.