Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 5/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24973049 | 1.00 | PDE9A (0.33) | PDE9APDE1BPDE5APDE4APDE4B | |
| SCHEMBL24973041 | 0.86 | KDM4E (0.32) | PDE9APDE1BPDE5APDE4APDE4B | |
| SCHEMBL25754152 | 0.86 | KDM4E (0.32) | PDE9APDE1BPDE5APDE4APDE4B | |
| SCHEMBL24971055 | 0.86 | KDM4E (0.32) | PDE9APDE1BPDE5APDE4APDE4B | |
| SCHEMBL25754146 | 0.86 | KDM4E (0.32) | PDE9APDE1BPDE5APDE4APDE4B | |
| SCHEMBL14570609 | 0.83 | TK1 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25996112 | 0.83 | TK1 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24973038 | 0.73 | PDE9A (0.31) | PDE9A | |
| SCHEMBL24973033 | 0.73 | PDE9A (0.31) | PDE9A | |
| SCHEMBL25754147 | 0.73 | PDE9A (0.31) | PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203083-A1 | NUCLEOTIDE ANALOGUES | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203083-A1 | NUCLEOTIDE ANALOGUES | ITPA, POLB, NUDT1 | PDE9A 659/4885PDE1B 3649/4885PDE5A 1371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.