Sugi Predict

Sugi Predict / Compounds / SCHEMBL2575424

SCHEMBL2575424

SCHEMBL2575424

CN(C)C=Cc1ncc(-c2cnn(C3CCN(C(=O)OC(C)(C)C)CC3)c2)cc1[N+](=O)[O-]

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 4/20 0.45
▸ FGFR1 P11362 2/20 0.43
▸ FGFR2 P21802 2/20 0.43
▸ FGFR4 P22455 2/20 0.43
▸ FGFR3 P22607 2/20 0.43
▸ KDR P35968 2/20 0.43
▸ FLT3 P36888 2/20 0.43
▸ GPR119 Q8TDV5 3/20 0.41
▸ RIPK2 O43353 1/20 0.41
▸ DDB1 Q16531 1/20 0.40
▸ CRBN Q96SW2 1/20 0.40
▸ TTK P33981 1/20 0.40
▸ TNK2 Q07912 1/20 0.40
▸ EGFR P00533 2/20 0.39
▸ LIPC P11150 1/20 0.39
▸ CCNC P24863 1/20 0.39
▸ CDK8 P49336 1/20 0.39
▸ USP30 Q70CQ3 1/20 0.38
▸ LCK P06239 1/20 0.38
▸ JAK3 P52333 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16286344 1.00 MET (0.45) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL2578937 0.85 MET (0.49) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL21526495 0.76 ALDH1A1 (0.54) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL22046247 0.76 MET (0.49) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL15416477 0.74 DDB1 (0.53) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL15416435 0.74 MET (0.53) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL1653749 0.74 TNK2 (0.56) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL1558660 0.74 DDB1 (0.52) GPR119DDB1CRBNTNK2CCNC
SCHEMBL2680817 0.73 MET (0.49) METFGFR1FGFR2FGFR4FGFR3
SCHEMBL31552970 0.73 CCNC (0.51) METFGFR1FGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8912330-B2 Azaindole derivatives as kinase inhibitors ARIAD PHARMACEUTICALS, INC. (US) 2014-12-16 — — US disclosed
US-8912330-B2 Azaindole derivatives as kinase inhibitors ARIAD PHARMACEUTICALS, INC. (US) 2014-12-16 — — US disclosed
US-8912330-B2 Azaindole derivatives as kinase inhibitors ARIAD PHARMACEUTICALS, INC. (US) 2014-12-16 — — US disclosed
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2011-12-01 — — US disclosed
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2011-12-01 — — US disclosed
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2011-12-01 — — US disclosed
EP-2381777-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD Pharmaceuticals, Inc (US) 2011-11-02 — — EP disclosed
WO-2010068292-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ARIAD PHARMACEUTICALS, INC. (US) 2010-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110294806-A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS ABL1, CDKN1A, MAP3K13 MET 627/4885FGFR1 954/4885FGFR2 788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.