SCHEMBL2575496

SCHEMBL2575496

COC(=O)[C@H](CCC(=O)c1ccc(F)c(F)c1)NC(=O)OC(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
MAPT P10636 3/20 0.45
TRPA1 O75762 1/20 0.42
CHRNA1 P02708 1/20 0.41
CHRNG P07510 1/20 0.41
CHRNB1 P11230 1/20 0.41
CHRNB2 P17787 1/20 0.41
SLC6A2 P23975 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA4 P43681 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CHRND Q07001 1/20 0.41
PPARG P37231 7/20 0.41
PPARA Q07869 7/20 0.41
KLK5 Q9Y337 1/20 0.41
PPARD Q03181 2/20 0.40
KDM4E B2RXH2 1/20 0.40
GAA P10253 1/20 0.40
PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2581127 0.93 ALDH1A1 (0.41) ALDH1A1MAPTTRPA1CHRNA1CHRNG
SCHEMBL2348573 0.91 MAPT (0.56) ALDH1A1MAPTTRPA1PPARGPPARA
SCHEMBL2348575 0.91 MAPT (0.56) ALDH1A1MAPTTRPA1PPARGPPARA
SCHEMBL4092912 0.90 PPARA (0.49) ALDH1A1MAPTTRPA1PPARGPPARA
SCHEMBL4092905 0.90 PPARA (0.49) ALDH1A1MAPTTRPA1PPARGPPARA
SCHEMBL4514578 0.90 PPARA (0.49) ALDH1A1MAPTTRPA1PPARGPPARA
SCHEMBL31470306 0.88 ALDH1A1 (0.40) ALDH1A1MAPTTRPA1PPARGPPARA
SCHEMBL23878363 0.87 ALDH1A1 (0.47) ALDH1A1MAPTPPARGPPARAKLK5
SCHEMBL22039756 0.87 ALDH1A1 (0.47) ALDH1A1MAPTPPARGPPARAKLK5
SCHEMBL31479840 0.85 CTSS (0.48) ALDH1A1MAPTPPARGPPARAKLK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8048878-B2 Two cyclic cinnamide compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-11-01 US disclosed