SCHEMBL25755068

SCHEMBL25755068

CNC(=O)COCC(N)CCCCn1ccnn1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PADI4 Q9UM07 2/20 0.34
DPP4 P27487 1/20 0.34
HDAC1 Q13547 1/20 0.33
CYP19A1 P11511 3/20 0.32
HTR4 Q13639 2/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
GPR88 Q9GZN0 1/20 0.30
CYP1A1 P04798 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25755081 0.96 PADI4 (0.35) PADI4DPP4HDAC1CYP19A1HTR4
SCHEMBL25755066 0.90 PADI4 (0.33) PADI4DPP4HDAC1CYP19A1HTR4
SCHEMBL25755063 0.90 PADI4 (0.33) PADI4DPP4HDAC1CYP19A1HTR4
SCHEMBL25755062 0.90 SLC6A2 (0.36) PADI4DPP4CYP19A1HTR4SLC6A2
SCHEMBL25754811 0.89 SLC6A2 (0.34) PADI4DPP4HDAC1HTR4SLC6A2
SCHEMBL25755064 0.88 DPP4 (0.32) PADI4DPP4HTR4SLC6A2SLC6A4
SCHEMBL25754814 0.86 DPP4 (0.34) PADI4DPP4HTR4SLC6A2SLC6A4
SCHEMBL25755078 0.86 PADI4 (0.33) PADI4DPP4CYP19A1CYP1A1
SCHEMBL25755072 0.84 DPP4 (0.39) PADI4DPP4HTR4SLC6A2SLC6A4
SCHEMBL25754812 0.81 CYP19A1 (0.34) HDAC1CYP19A1GPR88CYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM EUBULUS BIOTHERAPEUTICS (HONG KONG) LIMITED (HK) 2023-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM UCHL3, UBE2L3, ADAM33 PADI4 1134/4885DPP4 1068/4885HDAC1 596/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.