Sugi Predict

Sugi Predict / Compounds / SCHEMBL25756230

SCHEMBL25756230

SCHEMBL25756230

CCn1cc(C)c2c(c(NC(=O)OC(C)(C)C)cn2C)c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 1/20 0.40
▸ P2RX7 Q99572 1/20 0.34
▸ BRD4 O60885 3/20 0.33
▸ BRD2 P25440 2/20 0.33
▸ BRD3 Q15059 2/20 0.33
▸ CREBBP Q92793 1/20 0.33
▸ RORC P51449 1/20 0.32
▸ CA12 O43570 1/20 0.32
▸ CA1 P00915 1/20 0.32
▸ CA9 Q16790 1/20 0.32
▸ BRD9 Q9H8M2 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ CYP2C19 P33261 1/20 0.31
▸ KCNQ4 P56696 2/20 0.31
▸ KCNQ5 Q9NR82 2/20 0.31
▸ PDE10A Q9Y233 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27199670 0.84 MAPT (0.33) CNR2BRD4ALDH1A1MAPTHPGD
SCHEMBL25670769 0.79 CNR2 (0.42) CNR2P2RX7BRD4RORCALDH1A1
SCHEMBL25753867 0.76 P2RX7 (0.36) CNR2P2RX7BRD4BRD2BRD3
SCHEMBL25670962 0.76 CYP17A1 (0.37) CNR2P2RX7BRD4BRD2BRD3
SCHEMBL30895065 0.72 CNR2 (0.38) CNR2P2RX7ALDH1A1HPGDKDM4E
SCHEMBL25752777 0.72 CNR2 (0.39) CNR2BRD4CA12CA1CA9
SCHEMBL25756040 0.71 CNR2 (0.42) CNR2P2RX7ALDH1A1MAPTHPGD
SCHEMBL25670291 0.69 CNR2 (0.39) CNR2P2RX7BRD4BRD2BRD3
SCHEMBL4544314 0.69 CNR2 (0.39) CNR2CA12CA1CA9ALDH1A1
SCHEMBL25118297 0.69 KDM4E (0.50) CNR2ALDH1A1MAPTHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO LTD (CN) 2025-04-10 — — US disclosed
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-10-29 — — US disclosed
CN-118401516-A TYK2 inhibitors, compositions and methods thereof 凌科药业(杭州)有限公司 2024-07-26 — — CN disclosed
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-04-18 — — US disclosed
WO-2023109954-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2023-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 CNR2 3169/4885P2RX7 3505/4885BRD4 235/4885
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 CNR2 3169/4885P2RX7 3505/4885BRD4 235/4885
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof TYK2, JAK2, JAK1 CNR2 3169/4885P2RX7 3505/4885BRD4 235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.