Sugi Predict

Sugi Predict / Compounds / SCHEMBL25752777

SCHEMBL25752777

SCHEMBL25752777

CCOC(=O)Cn1ccc2c(c(NC(=O)OC(C)(C)C)cn2C)c1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 1/20 0.39
▸ LMNA P02545 1/20 0.38
▸ ALDH1A1 P00352 3/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ MEN1 O00255 1/20 0.36
▸ CRHBP P24387 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ CRHR2 Q13324 1/20 0.36
▸ BRD4 O60885 1/20 0.35
▸ PIN1 Q13526 1/20 0.34
▸ PIN4 Q9Y237 1/20 0.34
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA9 Q16790 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ TNF P01375 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ ESR2 Q92731 1/20 0.34
▸ JAK2 O60674 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25670769 0.87 CNR2 (0.42) CNR2ALDH1A1KDM4EBRD4ELANE
SCHEMBL30895065 0.84 CNR2 (0.38) CNR2LMNAALDH1A1KDM4EPOLB
SCHEMBL25752652 0.83 CNR2 (0.39) CNR2ALDH1A1KDM4EELANEMAPT
SCHEMBL25670291 0.81 CNR2 (0.39) CNR2KDM4EBRD4ELANE
SCHEMBL30895101 0.80 DRD2 (0.38) CNR2
SCHEMBL25752675 0.77 PPARA (0.40) CNR2BRD4CA12CA1L3MBTL1
SCHEMBL25750429 0.76 ELANE (0.38) CNR2BRD4ELANE
Hydrochloric Acid SCHEMBL27199364 0.76 ALDH1A1 (0.43) LMNAALDH1A1KDM4EMEN1CRHBP
SCHEMBL25756040 0.75 CNR2 (0.42) CNR2ALDH1A1KDM4EMEN1KMT2A
SCHEMBL25752562 0.74 OPRM1 (0.36) CNR2KMT2ABRD4L3MBTL1JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO LTD (CN) 2025-04-10 — — US disclosed
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-10-29 — — US disclosed
CN-118401516-A TYK2 inhibitors, compositions and methods thereof 凌科药业(杭州)有限公司 2024-07-26 — — CN disclosed
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-04-18 — — US disclosed
WO-2023109954-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2023-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 CNR2 3169/4885LMNA 974/4885ALDH1A1 4805/4885
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 CNR2 3169/4885LMNA 974/4885ALDH1A1 4805/4885
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof TYK2, JAK2, JAK1 CNR2 3169/4885LMNA 974/4885ALDH1A1 4805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.