Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | PREP | P48147 | 3/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646671 | 1.00 | FKBP1A (0.56) | FKBP1AHTR2CPREPTMEM97SIGMAR1 | |
| SCHEMBL14999594 | 0.99 | FKBP1A (0.55) | FKBP1AHTR2CPREPTMEM97SIGMAR1 | |
| SCHEMBL29889013 | 0.99 | FKBP1A (0.55) | FKBP1AHTR2CPREPTMEM97SIGMAR1 | |
| SCHEMBL1355639 | 0.96 | PREP (0.59) | HTR2CPREPACE2PDK1PDK2 | |
| SCHEMBL1355641 | 0.96 | PREP (0.59) | HTR2CPREPACE2PDK1PDK2 | |
| SCHEMBL15372095 | 0.96 | PREP (0.59) | HTR2CPREPACE2PDK1PDK2 | |
| SCHEMBL28411733 | 0.90 | HTR2C (0.59) | HTR2CPREPPDK1PDK2PDK3 | |
| SCHEMBL25841627 | 0.90 | HTR2C (0.59) | HTR2CPREPPDK1PDK2PDK3 | |
| SCHEMBL16925462 | 0.86 | PREP (0.56) | HTR2CPREPACE2PDK1PDK2 | |
| SCHEMBL5326054 | 0.84 | SMN1; SMN2 (0.55) | FKBP1APREPTMEM97SIGMAR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119080779-A | Pyrrolopyrimidine ITK inhibitors | 阿克拉瑞斯治疗股份有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-112823005-B | Pyrrolopyrimidine ITK inhibitors | 阿克拉瑞斯治疗股份有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-111918651-B | GCN2 inhibitors and uses thereof | 默克专利股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-117279910-A | Modulators of BCL6 proteolysis and related methods of use | 阿尔维纳斯运营股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-112888691-B | Pyrrolo [2,3-d ] pyrimidine tosylate, crystalline forms thereof, and related methods and intermediates for the preparation thereof | 辉瑞公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116615427-A | Substituted macrocyclic compounds and related methods of treatment | 阿尔克姆斯有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-116490184-A | Compounds for inhibiting EGFR mutant cancers and pharmaceutical uses thereof | J2H生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |
| EP-3746440-B1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | UNIV TEXAS (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022062601-A1 | PYRIMIDOPYRROLE COMPOUND | 江苏先声药业有限公司 | 2022-03-31 | — | — | WO | disclosed |
| CN-113677346-A | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2021-11-19 | — | — | CN | disclosed |
| CN-113226306-A | Methods of treating cancer in a patient identified by a biomarker using a non-covalent inhibitor of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-102471310-A | Bipyridines useful for the treatment of proliferative diseases | NOVARTIS AG | 2012-05-23 | — | — | CN | disclosed |
| CN-102459248-A | Benzoxepin as PI3K/mTOR inhibitors and methods of their use and manufacture | EXELIXIS INC | 2012-05-16 | — | — | CN | disclosed |
| CN-101687036-A | CHK1 inhibitors with b cell depleting antibodies for the treatment of hematologic malignancies | ASTRAZENECA AB | 2010-03-31 | — | — | CN | disclosed |