Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | CRHBP | P24387 | 1/20 | 0.67 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 11/20 | 0.66 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25755504 | 0.85 | MAPT (0.82) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25755514 | 0.84 | KMT2A (0.64) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25753999 | 0.81 | KMT2A (0.79) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL27181407 | 0.80 | MAPT (1.00) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30926791 | 0.80 | MAPT (1.00) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL27180374 | 0.80 | MAPT (0.79) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30926466 | 0.80 | MAPT (0.79) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25755590 | 0.79 | KMT2A (0.67) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL17980878 | 0.79 | KMT2A (0.61) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30926976 | 0.79 | MAPT (0.82) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, TP53BP1 | KMT2A 4864/4885MEN1 3902/4885LMNA 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.