Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606524 | 0.83 | CES2 (0.50) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL966453 | 0.81 | CES2 (0.49) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27946915 | 0.80 | CES2 (0.47) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL525760 | 0.79 | CES2 (0.45) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL28217598 | 0.79 | PTGIR (0.46) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11578705 | 0.78 | CES2 (0.45) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9264543 | 0.77 | PARP1 (0.48) | CES2ALDH1A1EPHX1PKMMEN1 | |
| SCHEMBL3389830 | 0.76 | HTR3E (0.46) | CES2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7739130 | 0.75 | CES2 (0.50) | CES2ALDH1A1MAPTLMNASRD5A2 | |
| SCHEMBL7738559 | 0.74 | SRD5A2 (0.52) | CES2ALDH1A1LMNASRD5A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283023-A1 | Dual-Curing Dental Compositions with High Stability | JAMES R. GLIDEWELL DENTAL CERAMICS, INC. | 2021-09-16 | — | — | US | disclosed |
| US-11020324-B2 | Dual-curing dental compositions with high stability | JAMES R. GLIDEWELL DENTAL CERAMICS, INC. (US) | 2021-06-01 | — | — | US | disclosed |
| US-20200268615-A1 | Dual-Curing Dental Compositions with High Stability | JAMES R. GLIDEWELL DENTAL CERAMICS, INC. | 2020-08-27 | — | — | US | disclosed |
| EP-1926719-B1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-31 | — | — | EP | disclosed |
| US-9388175-B2 | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-07-12 | — | — | US | disclosed |
| US-20110269748-A1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-11-03 | — | — | US | disclosed |
| EP-1926719-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031440-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269748-A1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | CHRNA4, CHRNA5, CHRNA7 | CES2 1240/4885HTR3E 62/4885HTR3B 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.