Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372000 | 0.74 | ALDH1A1 (0.46) | KDM4EALDH1A1ITGB1ITGA4 | |
| SCHEMBL15327837 | 0.74 | ALDH1A1 (0.46) | KDM4EALDH1A1ITGB1ITGA4 | |
| SCHEMBL5579426 | 0.69 | ALDH1A1 (0.53) | KDM4EALDH1A1 | |
| SCHEMBL27123348 | 0.69 | ALDH1A1 (0.53) | KDM4EALDH1A1 | |
| SCHEMBL23227257 | 0.69 | ALDH1A1 (0.41) | KDM4EALDH1A1ITGB1ITGA4 | |
| SCHEMBL13999499 | 0.68 | ALDH1A1 (0.44) | KDM4EALDH1A1ITGB1ITGA4HDAC4 | |
| SCHEMBL460242 | 0.68 | — | — | |
| SCHEMBL18766568 | 0.68 | ALDH1A1 (0.47) | KDM4EALDH1A1ITGB1ITGA4 | |
| SCHEMBL17849862 | 0.68 | ALDH1A1 (0.47) | KDM4EALDH1A1ITGB1ITGA4 | |
| SCHEMBL337149 | 0.67 | ALDH1A1 (1.00) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2011-11-09 | — | — | EP | disclosed |