Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431561 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL729060 | 0.82 | L3MBTL1 (0.46) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL24275924 | 0.81 | IKBKB (0.40) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL22257043 | 0.81 | MEN1 (0.36) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL25244879 | 0.81 | KDM4E (0.37) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL9194890 | 0.81 | KDM4E (0.42) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL1359424 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL25970279 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL19555815 | 0.79 | KDM4E (0.41) | SMN1; SMN2MEN1KMT2APRNPPOLB | |
| SCHEMBL11272207 | 0.79 | KDM4E (0.45) | SMN1; SMN2MEN1KMT2APRNPPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023098880-A1 | FUSED RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-06-08 | — | — | WO | disclosed |
| CN-111362967-B | Benzoxadiazatetetradecene derivatives and use thereof | 南京雷正医药科技有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-111362967-A | Benzoxadiazatetetradecene derivatives and use thereof | 南京雷正医药科技有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-101052625-A | As P2X7Adamantyl derivatives of receptor antagonists | ASTRAZENECA AB (SE) | 2007-10-10 | — | — | CN | disclosed |