Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18408144 | 1.00 | HSD11B1 (0.46) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL1207441 | 1.00 | HSD11B1 (0.46) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL1206012 | 1.00 | HSD11B1 (0.46) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL13753194 | 1.00 | HSD11B1 (0.46) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL1206319 | 0.85 | HSD11B1 (0.48) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL1396472 | 0.85 | SIGMAR1 (0.57) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL18407969 | 0.85 | SIGMAR1 (0.57) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL1207171 | 0.85 | SIGMAR1 (0.57) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL18408054 | 0.85 | HSD11B1 (0.48) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL1207393 | 0.85 | SIGMAR1 (0.57) | HSD11B1OPRM1OPRD1OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245014-B1 | UREA DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2011-11-02 | — | — | EP | disclosed |