Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 7/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30641925 | 0.77 | DPP4 (0.39) | DPP4DPP9AGBL2BACE1SYK | |
| SCHEMBL4326940 | 0.77 | DPP4 (0.39) | DPP4DPP9AGBL2BACE1SYK | |
| SCHEMBL1396222 | 0.76 | NR3C2 (0.32) | AGBL2NR3C2 | |
| SCHEMBL107626 | 0.76 | BACE1 (0.42) | DPP4DPP9AGBL2BACE1BACE2 | |
| Hydrochloric Acid SCHEMBL28375765 | 0.75 | DPP4 (0.39) | DPP4DPP9AGBL2BACE1SYK | |
| SCHEMBL1315200 | 0.71 | ALDH1A1 (0.42) | DPP4DPP9AGBL2BACE1BACE2 | |
| SCHEMBL107357 | 0.71 | HCAR2 (0.45) | DPP4DPP9AGBL2BACE1BACE2 | |
| SCHEMBL589530 | 0.71 | AGBL2 (0.34) | DPP4DPP9AGBL2BACE1BACE2 | |
| SCHEMBL4459170 | 0.70 | DPP4 (0.34) | DPP4DPP9AGBL2BACE1 | |
| SCHEMBL18784193 | 0.70 | AGBL2 (0.37) | DPP4DPP9AGBL2BACE1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |